新产品编号:1079433

Chemical Name: 6-Fluoro-9-[1-(hydroxymethyl)-2-(isobutyryloxy)ethoxymethyl]purine-2-amine
项目整合开发状态: Preclinical
项目研究机构: SK Pharma (Licensee)
合成路线:Treatment of 6-deoxy-6-chloroganciclovir (I) with trimethylamine in DMF-THF at low temperature produced the trimethylammonium salt (II),which was subsequently displaced with KF in DMF at 80 C under vacuum removal of the Me3N to afford the corresponding 6-fluoro derivative (III).Finally,monoacylation with one equivalent of isobutyric anhydride (IV) in the presence of DMAP provided the target ester.