Chemical Name: cis-(1,2-Diaminocyclohexane)(isocitrato) platinum (II) disodium salt dihydrate
项目整合开发状态: Biological Testing
项目研究机构: CNRS (Originator)
合成路线:PHIC is prepared from the diaquo derivative cis-[Pt(diaminocyclohexane)(H2O)2](NO3)2 (II),which is obtained by addition of a stoichiometric amount of silver nitrato to cis-[PtCl2(diaminocyclohexane)] (I).Then isocitrate trisodium salt is added to the diaquo species (II) (1:1),and the mixtures heated to 60 C in the dark for 20 h.The yellow solution is concentrated.then treated with cold ethanol acetona (1:1) to give white PHIC precipitate.After the usual workup,PHIC is obtained (85%).The binding sites of the isocitrate ion to the platinum: diamino cyclohexane moiety have not been characterized.
📄 详细内容
合成路线:PHIC is prepared from the diaquo derivative cis-[Pt(diaminocyclohexane)(H2O)2](NO3)2 (II),which is obtained by addition of a stoichiometric amount of silver nitrato to cis-[PtCl2(diaminocyclohexane)] (I).Then isocitrate trisodium salt is added to the diaquo species (II) (1:1),and the mixtures heated to 60 C in the dark for 20 h.The yellow solution is concentrated.then treated with cold ethanol acetona (1:1) to give white PHIC precipitate.After the usual workup,PHIC is obtained (85%).The binding sites of the isocitrate ion to the platinum: diamino cyclohexane moiety have not been characterized.
参考文献标题:Pharmacological and preclinical toxicological studies of 1,2-diaminocyclohexane(isocitrato)platinum (II)
文献作者:Macquet,J.P.; Cros,S.; Armand,J.P.
参考来源:Cancer Res 1984,44(9),3736
合成路线:PHIC is prepared from the diaquo derivative cis-[Pt(diaminocyclohexane)(H2O)2](NO3)2 (II),which is obtained by addition of a stoichiometric amount of silver nitrato to cis-[PtCl2(diaminocyclohexane)] (I).Then isocitrate trisodium salt is added to the diaquo species (II) (1:1),and the mixtures heated to 60 C in the dark for 20 h.The yellow solution is concentrated.then treated with cold ethanol acetona (1:1) to give white PHIC precipitate.After the usual workup,PHIC is obtained (85%).The binding sites of the isocitrate ion to the platinum: diamino cyclohexane moiety have not been characterized.
参考文献标题:New platinum complexes with anti-tumor activity
文献作者:Ross,W.C.J.; Khokkar,A.R.; Connors,T.A.; Jones,M.; Braddock,P.D.; Tobe,M.L.
参考来源:Chem Biol Interact 1972,5415-424
合成路线:PHIC is prepared from the diaquo derivative cis-[Pt(diaminocyclohexane)(H2O)2](NO3)2 (II),which is obtained by addition of a stoichiometric amount of silver nitrato to cis-[PtCl2(diaminocyclohexane)] (I).Then isocitrate trisodium salt is added to the diaquo species (II) (1:1),and the mixtures heated to 60 C in the dark for 20 h.The yellow solution is concentrated.then treated with cold ethanol acetona (1:1) to give white PHIC precipitate.After the usual workup,PHIC is obtained (85%).The binding sites of the isocitrate ion to the platinum: diamino cyclohexane moiety have not been characterized.
参考文献标题:Sulfato 1,2-diaminocyclohexane platinum (II): A potencial new antitumor agent
文献作者:Speer,R.J.; Zapata,A.; Hill,J.M.; Stewart,D.P.; Ridgway,H.; Hall,L.M.
参考来源:J Clin Hematol Oncol 1977,7210-219