710723-S
Chemical Name: N-[(1-Ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-(N-methylmethanesulfonamido)benzamide
项目整合开发状态: Biological Testing
项目研究机构: Shionogi (Originator)
合成路线:2-Methoxy-5-(N-methylmethanesulfonamido)-N-tetrahydrofurfurylbenzamide (II),which is prepared from (I) and tetrahydrofurfurylamine,is treated with SOCl2 in dichloroethane to give the dichloro compound (III).Treatment of (III) with EtNH2 gives title compound.
📌 参考资料/链接：
参考文献标题:Meta-sulfonamido-benzamides
文献作者:Masaru,O.; Hiroshi,M.(Shionogi & Co.Ltd.)
参考来源:DE 2803651; ES 466366; FR 2378758; GB 1557019; US 4328155; US 4328344; US 4330472; US 4350635; US 4351770; US 44313663
📄 详细内容
合成路线:5-(N-Methylmethanesulfonamido)benzoic acid (I) is treated with thionyl chloride and 2-amino-methyl-1-ethyl-pyrrolidine to give title compound.
合成路线:2-Methoxy-5-(N-methylmethanesulfonamido)-N-tetrahydrofurfurylbenzamide (II),which is prepared from (I) and tetrahydrofurfurylamine,is treated with SOCl2 in dichloroethane to give the dichloro compound (III).Treatment of (III) with EtNH2 gives title compound.
参考文献标题:710723-S
文献作者:Ogata,M.
参考来源:Drugs Fut 1985,10(9),758
合成路线:5-(N-Methylmethanesulfonamido)benzoic acid (I) is treated with thionyl chloride and 2-amino-methyl-1-ethyl-pyrrolidine to give title compound.
参考文献标题:Synthesis and neuroleptic activity of N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfonamidobenzamide s
文献作者:Ogata,M.; Matsumoto,H.; Kida,S.; Shiomi,T.; Eigyo,M.; Hirose,K.
参考来源:J Med Chem 1984,27(9),1137