HIPDM
Chemical Name: N,N,N'-Trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine dihydrochloride; 2-[[[3-(Dimethylamino)propyl]methylamino]methyl]]-4-iodo-6-methylphenol dihydrochloride
项目整合开发状态: Biological Testing
项目研究机构: State University of New York, Buffalo (Originator)
合成路线:The 5-methylsalicylaldehyde (I) is prepared by a tin (IV) chloride-catalyzed formylation.Iodination of the aldehyde with ICl in glacial acetic acid gives good yield of 3-methyl-5-iodobenzylaldehyde (III).The iodinated salicylaldehyde is reductively aminated with N,N,N'-trimethylpropane-1,3-diamine and sodium borohydride to give N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) (III) in excellent yield.
📌 参考资料/链接：
参考文献标题:HIPDM
文献作者:Kung,H.F.; Hostyniak,P.J.
参考来源:Drugs Fut 1985,10(9),742
📄 详细内容
合成路线:The 5-methylsalicylaldehyde (I) is prepared by a tin (IV) chloride-catalyzed formylation.Iodination of the aldehyde with ICl in glacial acetic acid gives good yield of 3-methyl-5-iodobenzylaldehyde (III).The iodinated salicylaldehyde is reductively aminated with N,N,N'-trimethylpropane-1,3-diamine and sodium borohydride to give N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3-propanediamine (HIPDM) (III) in excellent yield.
参考文献标题:Radioiodine-labeled N,N-dimethyl-N'-(2-hydroxy-3-a駅yl-5-iodobenzyl)-1,3.propanediamines for Brain Perfusion Imaging
文献作者:Tramposch,K.M.; Kung,H.F.; Blau,M.
参考来源:J Med Chem 1983,28(2),121-125