新产品编号:2511143
Chemical Name: 1-(2-Chlorophenyl)methanesulfonamide sodium salt monohydrate
项目整合开发状态: Biological Testing
项目研究机构: University of North Carolina (Originator)
合成路线:Reaction of o-chlorobenzyl chloride (I) with thiourea (A) in refluxing ethanol affords the isothiourea hydrochloride (II),which is treated with chlorine gas in aqueous solution equal or lower at 10 C to afford the corresponding sulfonyl chloride (III).Exposure of (III) to liquid ammonia smoothly converts (III) to the sulfonamide (IV),which is converted to the sodium salt monohydrate with ethanolic sodium hydroxide.
📌 参考资料/链接：
参考文献标题:o-Chlorobenzylsulfonamide Sodium Salt
文献作者:Wyrick,S.D.; Hall,I.H.
参考来源:Drugs Fut 1985,10(4),277
📄 详细内容
合成路线:Reaction of o-chlorobenzyl chloride (I) with thiourea (A) in refluxing ethanol affords the isothiourea hydrochloride (II),which is treated with chlorine gas in aqueous solution equal or lower at 10 C to afford the corresponding sulfonyl chloride (III).Exposure of (III) to liquid ammonia smoothly converts (III) to the sulfonamide (IV),which is converted to the sodium salt monohydrate with ethanolic sodium hydroxide.
参考文献标题:Structure-activity studies on antihyperlipidemic N-benzoylsulfamates,N-benzylsulfamates and benzylsulfonamides
文献作者:Dubey,A.; Hall,I.H.; Wyrick,S.D.
参考来源:J Pharm Sci 1984,73374-377