SB-691673
Chemical Name: 2-[2-[4-(5-Fluoro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl]-2,3,4,5-tetrahydro-1H-2-benzazepin-1-one
项目整合开发状态: Biological Testing
项目研究机构: GlaxoSmithKline (Originator)
合成路线:Benzazepinone (I) is alkylated by allyl bromide (II) in the presence of NaH to furnish (III).Ozonolysis of the N-allyl group of (III) in cold CH2Cl2 then produces aldehyde (IV).This is then reductively aminated with 5-fluoro-1-(piperidin-4-yl)-2,3-dihydro-1H-benzimidazol-2-one (V) employing NaBH(OAc)3 in 1,2-dichloroethane to yield the title compound.
📌 参考资料/链接：
参考文献标题:Identification of a novel series of selective 5-HT7 receptor antagonists
文献作者:Forbes,I.T.; Cooper,D.G.; Dodds,E.K.; Douglas,S.E.; Gribble,A.D.; Ife,R.J.; Lightfoot,A.P.; Meeson,M.; Campbell,L.P.; Coleman,T.; Riley,G.J.; Thomas,D.R.
参考来源:Bioorg Med Chem Lett 2003,13(6),1055