新产品编号:2455773

Chemical Name: 2-[2-(Dimethylamino)ethyl]-6-[2-(dimethylamino)ethylamino]-8,11-dihydroxy-3,7-dihydro-2H-dibenzo[de,h]cinnoline-3,7-dione
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Camerino (Originator), Politechnika Gdanska (Licensee)
合成路线:Treatment of 1,4-di(benzyloxy)-5,8-dichloro-9,10-dihydro-9,10-anthracenedione (I) with CuCN in hot DMA results in the desired monosubstituted derivative (II).Subsequent basic hydrolysis of the nitrile group of (II) leads to carboxylic acid (III).After conversion of (III) into the corresponding acid chloride (IV) by means of PCl5,reaction with 2-(dimethylamino)ethylhydrazine (V) produces the tetracyclic compound (VI).Displacement of the remaining chloride of (VI) with 2-(dimethylamino)ethylamine (VII) in DMA then gives (VIII).The protecting benzyl groups of (VIII) are finally removed with trifluoroacetic acid to furnish the title compound.