新产品编号:2452609

Chemical Name: N,N-Dimethyl-N-[2-(6-nitro-2-oxo-3,7-dihydro[1,2,6]thiadiazino[3,4,5-kl]acridin-3-yl)ethyl]amine maleate
项目整合开发状态: Preclinical
项目研究机构: Medical University of Gdansk (Originator), Politechnika Gdanska (Originator), Universit?degli Studi di Camerino (Originator)
合成路线:1-Chloro-4-nitro-9,10-dihydroacridin-9-one (I) is refluxed with POCl3 in the presence of a catalytic amount of DMF and subsequently reacted with ammonium carbonate in hot phenol to provide the amino acridine (II).Displacement of the 4-chloro group of (II) with N,N-dimethylethanediamine (III) in DMF at 100 C leads to amine (IV).Cyclization of (IV) with SOCl2 yields the target thiadiazinoacridine,which is finally isolated as the corresponding maleate salt.