新产品编号:2449445
Chemical Name: N,N'-(Octane-1,8-diyl)bis[6-[N-ethyl-N-(2-methoxybenzyl)amino]-N-methylhexanamide] dioxalate
项目整合开发状态: Biological Testing
项目研究机构: Universit?degli Studi di Bologna (Originator), Universit?degli Studi di Camerino (Originator)
合成路线:Condensation of diamine (I) with 2-methoxybenzaldehyde (II),followed by NaBH4 reduction of the intermediate bis-imine (III) gives rise to the benzylic amine (IV).This is then alkylated with diethyl sulfate,and the resultant N-ethyl amine is finally isolated as the corresponding dioxalate salt.
📌 参考资料/链接：
参考文献标题:Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone.2.Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine
文献作者:Tumiatti,V.; Rosini,M.; Bartolini,M.; Cavalli,A.; Marucci,G.; Andrisano,V.; Angeli,P.; Banzi,R.; Minarini,A.; Recanatini,M.; Melchiorre,C.
参考来源:J Med Chem 2003,46(6),954