URB-597

Chemical Name: N-Cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi "La Sapienza" (Originator), Universit?degli Studi di Bari (Originator), Universit?degli Studi di Napoli (Originator), Universit?degli Studi di Parma (Originator), Universit?degli Studi di Urbino (Originator), University of Calif
合成路线:Hydrolysis of 3-bromobenzonitrile (I) by means of sodium perborate leads to amide (II).Subsequent Suzuki coupling of 3-bromobenzamide (II) with 3-methoxyphenylboronic acid (III) furnishes the biphenyl compound (IV).The methyl ether group of (IV) is then cleaved employing BBr3 to yield phenol (V).This is finally coupled with cyclohexyl isocyanate (VI) to produce the title carbamate.