新产品编号:2427297

Chemical Name: 6-Amino-2-phenyl-1-(beta-D-ribofuranosyl)imidazo[4,5-e][1,3]diazepine-4,8(1H,5H)-dione
项目整合开发状态: Biological Testing
项目研究机构: Nabi Biopharmaceuticals (Originator), University of Maryland (Originator), Utah State University (Originator)
合成路线:Glycosylation of dimethyl 2-phenylimidazole-4,5-dicarboxylate (I) with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (II) in the presence of hexamethyldisilazane,chlorotrimethylsilane and trifluoromethanesulfonic acid leads to the imidazole ribofuranoside (III).Then,cyclization of the imidazoledicarboxylate (III) with guanidine (IV),and simultaneous alcoholysis of the ribose ester groups in the presence of methanolic NaOMe gives rise to the target imidazodiazepine ribofuranoside