JWH-229

Chemical Name: (6aR,10aR)-3-(1,1-Dimethylhexyl)-1-methoxy-6,6,9-trimethyl-6a,7,10,10a-tetrahydro-6H-dibenzo[b,d]pyran
项目整合开发状态: Biological Testing
项目研究机构: Clemson University (Originator), Virginia Commonwealth University (Originator)
合成路线:Condensation of 5-(1,1-dimethylhexyl)resorcinol (I) with (1S,4R)-4-isopropenyl-1-methyl-2-cyclohexenol (II) under acidic conditions furnishes the tetrahydrocannabinol derivative (III).The phenolic hydroxyl of (III) is then alkylated by iodomethane in the presence of NaOH to afford the target methyl ether.