VL-0395

Chemical Name: N-[2-(1H-Indol-2-ylcarboxamido)benzoyl]-DL-phenylalanine
项目整合开发状态: Preclinical
项目研究机构: Rotta (Originator)
合成路线:Condensation of isatoic anhydride (I) with DL-phenylalanine ethyl ester (II) affords anthranilamide (III).Subsequent acylation of amino amide (III) with indole-2-carbonyl chloride (IV) provides diamide (V).The ethyl ester group of (V) is finally hydrolyzed to the target carboxylic acid with methanolic KOH