新产品编号:2416223

Chemical Name: N-[2-(4'-Chlorobiphenyl-4-yl)acetyl]-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonyl-glycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartyl-glycyl-D-seryl-threo-3-methyl-L-glutamyl-gamma-(2-aminophenyl)-gamma-oxo-L-alpha-aminobutyric acid C- 1.13- O-2.4-lacton
项目整合开发状态: Preclinical
项目研究机构: Cubist (Originator)
合成路线:Enzymatic hydrolysis of the N-decanoyl moiety of the daptomycin derivative (I) employing deacylase from Actinoplanes utahensis gives the aminoacid core (II).Reacylation of (II) with 4'-chloro-4-biphenylylacetic acid (III) via activation with DCC and pentafluorophenol affords amide (IV).

合成路线:The N-Boc group of (IV) is finally removed by treatment with trifluoroacetic acid to furnish the title compound.