VRC-3885

Chemical Name: N-[3-[3-Fluoro-4-(1-oxothiomorpholin-4-yl)phenyl]-2-oxooxazolidin-5(S)-ylmethyl]-3-[4-(methoxyiminomethyl)phenyl]-2-propenamide
项目整合开发状态: Biological Testing
项目研究机构: Vicuron Pharmaceuticals (Originator)
合成路线:The title compound is prepared by solid phase synthesis utilizing a chloro-derivatized Sasrin resin.Coupling of aminomethyl oxazolidinone (I) to the chloromethyl resin affords the amine bound resin (II).This is then acylated with the cinnamic acid derivative (III) by means of HATU to furnish the corresponding amide (IV).Finally,cleavage of the target amide from resin (IV) is effected by treatment with 10% trifluoroacetic acid in CH2Cl2.