OPT-11

Chemical Name: 1-O,1'-O-(Butane-1,4-diyl)bis(methylimino)bis[1(S)-hydroxyethylene]bis(oxy)bis[4(R),6(S)-diamino-3(S)-hydroxycyclohexan-2(R),1(R)-diyl]bis(2,6-diamino-2,6-dideoxy-alpha-D-glucopyranose)
项目整合开发状态: Preclinical
项目研究机构: Optimer Pharmaceuticals (Originator)
合成路线:The protected azidoglycoside derivative (I) is condensed with (R)-glycidol tosylate (II) to produce the glycidyl ether (III).Epoxide opening in (III) with N,N'-dimethyl-1,4-butanediamine (IV) furnishes the diamine-linked bis azidoglycoside (V).The title compound is then obtained by simultaneous reduction of the azido groups and O benzyl groups cleavage in (V) upon catalytic hydrogenation over Pearlman's catalyst.