新产品编号:2413059
Chemical Name: N-[2-(1H-Indol-3-yl)ethyl]-3-[3-(2-thiazolyl)ureido]benzenesulfonamide; N-[3-[N-[2-(1H-Indol-3-yl)ethyl]sulfamoyl]phenyl]-N'-(2-thiazolyl)urea
项目整合开发状态: Preclinical
项目研究机构: Bayer (Originator)
合成路线:2-Aminothiazole (I) is coupled to 3-fluorosulfonylphenyl isocyanate (II) producing the diaryl urea (III).Subsequent reaction of sulfonyl fluoride (III) with tryptamine (IV) in hot acetonitrile furnishes the target sulfonamide.
📌 参考资料/链接：
参考文献标题:Phenyl-thiazolylurea-sulfonamides as novel inhibitors of phenylalanine-tRNA synthetase
文献作者:Beyer,D.; Kroll,H.; Bauser,M.; Siegel,S.; Brotz,H.; Endermann,R.; Schiffer,G.; Ziegelbauer,K.; Habich,D.; Pohlmann,J.
参考来源:42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002,San Diego) 2002,Abst F-756