ST-1863

Chemical Name: 2-[3-[2-(4-Chlorophenyl)ethoxy]benzyl]malonic acid dimethyl diester
项目整合开发状态: Preclinical
项目研究机构: Sigma-Tau (Originator)
合成路线:Knoevenagel condensation of 4-hydroxybenzaldehyde (I) with dimethyl malonate in the presence of pyridinium acetate affords the benzylidene malonate (II),which is further hydrogenated over Pd/C to furnish dimethyl (4-hydroxybenzyl)malonate (III).Then,Mitsunobu coupling between phenol (III) and 4-chlorophenethyl alcohol (IV) gives rise to the title compound.