新产品编号:2400403

Chemical Name: 6-[1-[6-Cyano-2'-(trifluoromethyl)biphenyl-3-yl]-1-(1-methyl-1H-imidazol-5-yl)methoxymethyl]-2-(3-hydroxypiperidin-1-yl)pyridine-3-carbonitrile
项目整合开发状态: Biological Testing
项目研究机构: Abbott (Originator)
合成路线:Suzuki coupling between 2-bromo-4-formylbenzonitrile (I) and 2-(trifluoromethyl)phenylboronic acid (II) affords the biphenyl aldehyde (III).The lithiated derivative of imidazole (IV) is then added to aldehyde (III),producing carbinol (V).Alkylation of (V) with the bromomethylpyridine (VI) by using Ag2O yields ether (VII).The chlorine atom of (VII) is finally displaced with 3-hydroxypiperidine (VIII) to provide the title compound.