111In-DTPA-Abeta(3-40)

Chemical Name: [N-[2-[N-[2-[N,N-Bis(carboxymethyl)amino]ethyl]-N-(carboxymethyl)amino]ethyl]-N-(carboxymethyl)glycyl-L-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-aspartyl-L-seryl-glycyl-L-tyrosyl-L-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl
项目整合开发状态: Preclinical
项目研究机构: University of California, Los Angeles (Originator), University of Cincinnati (Originator), University of Minnesota (Originator)
合成路线:The resin-bound A-beta(3-40) amyloid peptide (I) is prepared by solid-phase synthesis,employing Fmoc chemistry.Acylation of the peptide-resin (I) with diethylenetriaminepentaacetic (DTPA) dianhydride (II) gives rise to the peptide DTPA-amide (III),which is further liberated from the resin to produce (IV)