新产品编号:2384583
Chemical Name: N-[2-(Dimethylamino)ethyl]-6,10-dimethyl-10H-indolo[3,2-b]quinoline-4-carboxamide
项目整合开发状态: Preclinical
项目研究机构: La Trobe University (Originator), University of Auckland (Originator)
合成路线:Methylation of 6-methyl-10H-quindoline-4-carboxylic acid (I) with iodomethane in the presence of KOH in DMSO takes place at both the indole N and the carboxylate group,producing (II).Subsequent aminolysis of ester (II) with N,N-dimethylethanediamine (III) in refluxing dioxan furnishes the target amide.
📌 参考资料/链接：
参考文献标题:Synthesis and cytotoxic activity of N-(2-diethylamino)ethylcarboxamide and other derivatives of 10H-quindoline
文献作者:Chen,J.; Deady,L.W.; Kaye,A.J.; Finlay,G.J.; Baguley,B.C.; Denny,W.A.
参考来源:Bioorg Med Chem 2002,10(7),2381