新产品编号:2383001

Chemical Name: 10-[4-[4-(2-Hydroxyethyl)piperazin-1-yl]butyl]-2-methoxyacridin-9(10H)-one
项目整合开发状态: Biological Testing
项目研究机构: Georgetown University (Originator), St. Jude Children's Res. Hosp. (Originator), University of Mysore (Originator), University of Tennessee, Memphis (Originator)
合成路线:Ullmann condensation between o-chlorobenzoic acid (I) and p-anisidine (II) produces the diphenylamine carboxylic acid (III),which is further cyclized to the 2-methoxyacridone (IV) by heating in polyphosphoric acid.N-Alkylation of acridone (IV) with 1-bromo-4-chlorobutane (V) in the presence of KOH under phase-transfer conditions furnishes the N-(chlorobutyl)acridone (VI).Finally,nucleophilic substitution of the chloro group of (VI) with N-(2-hydroxyethyl)piperazine (VII) gives rise to the title compound.