新产品编号:2375091

Chemical Name: 4,6-Dimethyl-2H-pyrano[2,3-b]thieno[3,2-e]pyridin-2-one
项目整合开发状态: Preclinical
项目研究机构: Consiglio Nazionale delle Ricerche (Originator), Universit?degli Studi di Padova (Originator)
合成路线:Condensation of 4-methyl-7-hydroxypyrano[2,3-b]pyridin-2-one (I) with N,N-dimethylthiocarbamoyl chloride gives the thiocarbamate (II),which undergoes thermal rearrangement at 220 C to the S-aryl thiocarbamate isomer (III).Subsequent alkaline hydrolysis of (III) provides the 7-mercapto azacoumarin (IV).Alkylation of (IV) with chloroacetone (V) affords thioether (VI).This compound is finally cyclized to the target pyranothienopyridine compound under alkaline conditions.