新产品编号:2373509

Chemical Name: 5-[3-(Dimethylamino)propyl]-6-oxo-5,6-dihydrothieno[3',2':4,5]thieno[2,3-c]quinoline-9-carboxylic acid methyl ester hydrochloride
项目整合开发状态: Biological Testing
项目研究机构: Rudjer Boskovic Institute (Originator), University of Zagreb (Originator)
合成路线:Jones oxidation of 4-bromothiophene-2-carbaldehyde (I) leads to acid (II),which is further esterified with H2SO4/MeOH to furnish methyl 4-bromothiophene-2-carboxylate (III).Subsequent Heck coupling of aryl bromide (III) with cyclohexylammonium acrylate (IV) gives rise to the thienylacrylic acid (V).Cyclization of (V) with SOCl2 in the presence of pyridine produces the thienothiophene derivative (VI).Acid chloride (VI) is then coupled to N-(dimethylaminopropyl)aniline (VII) under Schotten-Baumann conditions,yielding amide (VIII).Finally,photochemical cyclization of (VIII) affords the target tetracyclic compound.