新产品编号:2371927

Chemical Name: N-[2-[4-(Methylsulfonamido)phenyl]ethyl]-N-[2-(naphthalen-1-yloxy)ethyl]acetamide
项目整合开发状态: Biological Testing
项目研究机构: China Pharmaceutical University (Originator), Chinese Academy of Sciences (Originator)
合成路线:Alkylation of 1-napthol (I) with 1,2-dibromoethane provides the (naphthyloxy)ethyl bromide (II),which is condensed with p-nitrophenethylamine (III) to afford the secondary amine (IV).After acetylation of amine (IV) to produce acetamide (V),the nitro group of (V) is reduced by means of iron and HCl,yielding aniline (VI).Finally,acylation of the amino group of (VI) with methanesulfonyl chloride furnishes the target sulfonamide.