新产品编号:2370345
Chemical Name: 2-[4-(Allyloxy)-3-(trifluoromethoxy)phenyl]-4,5-dihydrooxazole-4-carbohydroxamic acid
项目整合开发状态: Biological Testing
项目研究机构: Chiron (Originator)
合成路线:Coupling of 4-allyloxy-3-trifluoromethoxybenzoic acid (I) with D-serine methyl ester (II) using HATU/HOAt affords amide (III).Subsequent treatment of the benzoyl serine derivative (III) with diethylaminosulfur trifluoride gives rise to the oxazoline (IV).Finally,displacement of the methyl ester group of (IV) with hydroxylamine in the presence of NaOMe produces the title racemic hydroxamic acid
📌 参考资料/链接：
参考文献标题:Potent,novel in vitro inhibitors of the Pseudomonas aeruginosa deacetylase LpxC
文献作者:Kline,T.; Andersen,N.H.; Harwood,E.A.; Bowman,J.; Malanda,A.; Endsley,S.; Erwin,A.L.; Doyle,M.; Fong,S.; Harris,A.L.; Mendelsohn,B.; Mdluli,K.; Raetz,C.R.H.; Stover,K.; Witte,P.R.; Yabannavar,A.; Zhu,S.
参考来源:J Med Chem 2002,45(14),3112