新产品编号:2368763
Chemical Name: 2(R)-[4-(7-Bromoquinolin-2-yloxy)phenoxy]propionic acid
项目整合开发状态: Preclinical
项目研究机构: Karmanos Cancer Institute (Originator), Walker Cancer Research Institute (Originator), Wayne State University (Originator)
合成路线:The title diaryl ether is prepared by condensation between 7-bromo-2-chloroquinoline (I) and (R)-2-(4-hydroxyphenoxy)propionic acid (II) in the presence of K2CO3 in hot DMF.
📌 参考资料/链接：
参考文献标题:II.Synthesis and biological evaluation of some bioisosteres and congeners of the antitumor agent,2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenox}propionic acid (XK469)
文献作者:Hazeldine,S.T.; Polin,L.; Kushner,J.; White,K.; Bouregeois,N.M.; Crantz,B.; Palomino,E.; Corbett,T.H.; Horwitz,J.P.
参考来源:J Med Chem 2002,45(14),3130