新产品编号:2367181

Chemical Name: N-(4-Chlorophenyl)-4-(6,7-dimethoxyquinazolin-4-yl)piperazine-1-carboxamide
项目整合开发状态: Preclinical
项目研究机构: Kyowa Hakko (Originator), Millennium (Originator)
合成路线:The title urea derivative was synthesized by condensation of 6,7-dimethoxy-4-piperazinylquinazoline (I) with 4-bromophenyl isocyanate (II) in refluxing ethanol.

合成路线:The condensation of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline (I) with 4-bromophenylamine (II) by means of CDI or triphosgene gives the target piperazine-1-carboxamide.Alternatively,the reaction of 4-bromophenylamine (II) with 4-nitrophenyl chloroformate (III) by means of TEA gives the carbamate (IV),which is finally condensed with the quinazoline (I) in hot NMP to yield the target piperazine-1-carboxamide.

合成路线:The target piperazine-1-carboxamide has been obtained by several different methods:1.- The condensation of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline (I) with 4-chlorophenyl isocyanate (II) in DMF gives the target compound.2.- The condensation of 6,7-dimethoxy-4-(1-piperazinyl)quinazoline (I) with 4-chlorophenylamine (III) by means of CDI or triphosgene also gives the target piperazine-1-carboxamide.3.- The reaction of 4-chlorophenylamine (III) with 4-nitrophenyl chloroformate (IV) by means of TEA gives the carbamate (V),which is finally condensed with the quinazoline (I) in hot NMP to yield the target piperazine-1-carboxamide.