新产品编号:2365599

Chemical Name: 2-O-[N-[4-[N-(2,4-Diaminopteridin-6-ylmethyl)-N-methylamino]benzoyl]-L-glutamyl]-3-O-[2-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyloxy]-sn-glycero-3-O-phosphocholine inner salt
项目整合开发状态: Biological Testing
项目研究机构: Indiana University (Originator), Marshall University (Originator), Purdue University (Originator)
合成路线:Esterification of L-alpha-glycerophosphorylcholine (I) with docosahexaenoic acid (II) by means of DCC affords diester (III),which is regioselectively converted to mono-ester (IV) by phospholipase A2-catalyzed hydrolysis.Finally,acylation of (IV) with methotrexate (V) in the presence of DCC gives rise to the title compound.