新产品编号:2362435

Chemical Name: N2-[2(S)-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N1-[1(S)-(hydroxymethyl)-4-phenylbutyl]-L-alaninamide
项目整合开发状态: Biological Testing
项目研究机构: Elan (Originator), Lilly (Originator)
合成路线:Coupling between methyl 2-amino-5-phenylpentanoate (I) and N-Boc-alanine (II) affords dipeptide (III).Deprotection of (III) with trifluoroacetic acid yields amine (IV),which is then acylated with (S)-3,5-difluoromandelic acid (V),producing amide (VI).Finally,ester group reduction using LiBH4 leads to the desired alcohol.