新产品编号:2349779

Chemical Name: N'-(2-Chlorophenyl)-N-(3-ethynylphenyl)-2-oxopropanehydrazonamide
项目整合开发状态: Biological Testing
项目研究机构: Bristol-Myers Squibb (Originator)
合成路线:2-Chloroaniline (I) is diazotized with NaNO2/HCl and the resultant diazonium salt (II) is further coupled to 2,4-pentanedione (III) to furnish the diketo hydrazone (IV).Subsequent bromination of (IV) with Br2 in Ac2O/AcOH gives rise to the hydrazonyl bromide (V).This is finally condensed with 3-ethynylaniline (VI) in DMF to provide the corresponding aryl amidrazone.