NSC-711616
Chemical Name: (E)-3-(2-Chloro-5-methoxy-6-methyl-1H-indol-3-ylmethylidene)-2,3-dihydro-1H-indol-2-one
项目整合开发状态: Preclinical
项目研究机构: Lithuanian Institute of Cardiology (Originator), Universit?degli Studi di Bologna (Originator)
合成路线:The Vilsmeier formylation of 5-methoxy-6-methyloxindole (I) with DMF/POCl3 gives rise to the chloro aldehyde (II).This is then condensed with oxindole (III) in methanol in the presence of piperidine to furnish the target bis-indole derivative.
📌 参考资料/链接：
参考文献标题:Synthesis and antitumor activity of 1,5,6-substituted E-3-(2-chloro-3-indolylmethylene)-1,3-dihydroindol-2-ones
文献作者:Andreani,A.; Granaiola,M.; Leoni,A.; Locatelli,A.; Morigi,R.; Rambaldi,M.; Garaliene,V.
参考来源:J Med Chem 2002,45(12),2666