新产品编号:2314975

Chemical Name: 3-[2-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]-2-[4-(dimethylamino)phenyl]quinazolin-4(3H)-one
项目整合开发状态: Biological Testing
项目研究机构: Xenova (Originator)
合成路线:The title compound can be synthesized by two routes.Condensation of anthranilic acid (I) with acid chloride (II) provides benzooxazinone (III).Refluxing of (III) with amine (IV) in the presence of p-toluenesulfonic acid yields a mixture of the target quinazolinone and the uncyclized diamide (V),which can be cyclized to the title compound by heating in H2SO4/HOAc.

合成路线:The anthranilic amide (I) is converted to the corresponding iminophosphorane (II) by treatment with triphenylphosphine,hexachloroethane and triethylamine.Subsequent condensation of (II) with acid chloride (III) gives rise to the desired quinazolinone.