ProVP-16II

Chemical Name: [5R-[5alpha,5abeta,8aalpha,9beta(R*)]]-5-[4-(2,3-Dihydroxypropoxycarbonyloxy)-3,5-dimethoxyphenyl]-9-(4,6-O-ethylidene-beta-D-glucopyranosyloxy)-5,5a,6,8,8a,9-hexahydro-2H-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6-one; 4'-O-(2,3-Dihydroxypropoxycarbonyl)
项目整合开发状态: Biological Testing
项目研究机构: Humboldt-Universit鋞 zu Berlin (Originator), Tel Aviv University (Originator)
合成路线:Condensation of etoposide (I) with 2,2-dimethyl-1,3-dioxolan-4-ylmethyl chloroformate (II) provides the carbonate ester (III).Then,acidic hydrolysis of the acetonide group of (III) leads to the target compound.