新产品编号:2308647

Chemical Name: 3-(2-Benzyl-10-hydroxy-5-oxo-2,3,4,5-tetrahydro-1H-1-benzopyran[4,3-c]pyridin-8-yl)butyric acid ethyl ester
项目整合开发状态: Preclinical
项目研究机构: Kos Pharmaceuticals (Originator), University of Florida (Originator)
合成路线:Horner-Emmons condensation of 3',5'-di(benzyloxy)acetophenone (I) with triethyl phosphonoacetate yields the unsaturated ester (II).Catalytic double bond hydrogenation in (II),with simultaneous benzyl group hydrogenolysis,leads to the substituted resorcinol (III).This is then subjected to Pechmann cyclization with ethyl 1-benzyl-3-oxopiperidine-4-carboxylate (IV) in the presence of H2SO4 and POCl3 to provide the target benzopyranopyridine compound.