AMCPy

Chemical Name: 1-Acetoxy-2,2,5,5-tetramethylpyrrolidine-3-carboxylic acid methyl ester
项目整合开发状态: Preclinical
项目研究机构: National Institutes of Health (Originator)
合成路线:Bubbling dry HCl through a methanol solution of 1-oxyl-3-carboxy-2,2,5,5-tetramethylpyrrolidine (I) for a short period of time leads to the nitroxide radical methyl ester (II).Reduction of (II) to the hydroxylamine (III) is then accomplished by treatment with hydrazine in MeOH.Alternatively,upon treatment of (I) with HCl/MeOH for longer than 24 h,this undergoes both esterification and reduction to the hydroxylamine methyl ester (III).Further acetylation of hydroxylamine (III) by using Ac2O in the presence of Et3N yields the title compound.