新产品编号:2302319
Chemical Name: N-(Benzyloxycarbonyl)-L-valyl-N1-[4-[4-[(5R,5aR,8aR,9S)-9-[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methylperhydropyrano[3,2-d][1,3]dioxin-6-yloxy]-6-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl]-2,6-dimethoxyphenoxymethyl]phenyl]
项目整合开发状态: Biological Testing
项目研究机构: Seattle Genetics (Originator)
合成路线:The title prodrug has been obtained by condensation of the peptide (I) with etoposide (II) by means of PPh3 and DIAD in DMF.
📌 参考资料/链接：
参考文献标题:Protease-mediated fragmentation of p-amidobenzyl ethers: A new strategy for the activation of anticancer prodrugs
文献作者:Toki,B.E.; Cerveny,C.G.; Wahl,A.F.; Senter,P.D.
参考来源:J Org Chem 2002,67(6),1866