新产品编号:2300737

Chemical Name: N-[4-[3-(1-Methyl-1H-pyrrol-2-yl)-1-(2-phenoxybutyryl)-4,5-dihydro-1H-pyrazol-5-yl]phenyl]acetamide
项目整合开发状态: Preclinical
项目研究机构: AstraZeneca (Originator)
合成路线:Aldol condensation between 2-acetyl-1-methylpyrrole (I) and p-acetamidobenzaldehyde (II) affords the chalcone (III).Cyclization of (III) with hydrazine in EtOH gives rise to the pyrazoline (IV).Subsequent acylation of (IV) with 2-bromobutyryl chloride (V) furnishes amide (VI).Then,displacement of the bromide ion of (VI) with phenol in the presence of K2CO3 and NaI provides the title compound