CMPD1, AXC-06728
Chemical Name: 5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-ylmethyl)-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:The reaction of 5-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)furan-2-carboxylic acid (I) with SOCl2 gives the corresponding acyl chloride (II),which is then condensed with 2,4,6-trimethoxyaniline (III) to afford the target carboxamide.
📌 参考资料/链接：
参考文献标题:Non-peptide GnRH agent,methods and intermediates for their preparation
文献作者:Hong,Y.; Anderson,M.B.; Li,H.; Tompkins,E.V.; Luthin,D.R.; Faust,J.; Vazir,H.N.; Paderes,G.D.; Pathak,V.P.; Christie,L.C.(Agouron Pharmaceuticals,Inc.)
参考来源:EP 1105120; WO 0020358