新产品编号:2299155

Chemical Name: 5-(Guanin-9-ylmethyl)-4(S)-hydroxytetrahydrofuran-2(S)-phosphonic acidammonium salt
项目整合开发状态: Biological Testing
项目研究机构: Shire BioChem (Originator)
合成路线:The condensation between mesylate (I) and 2-amino-6-chloropurine (II) in the presence of Cs2CO3 affords nucleoside (III).Hydrolysis of (III) with trimethylsilyl bromide,followed by refluxing with HCl,provides the target phosphonic acid,which is finally isolated as the corresponding ammonium salt.