新产品编号:2295991

Chemical Name: N-[4-[(6aS)-2-Chloro-5,6,6a,7,8,9,10,12-octahydro-7,10-methanopyrido[2,1-c][1,4]benzodiazepin-5-ylcarbonyl]phenyl]-4'-methylbiphenyl-2-carboxamide
项目整合开发状态: Preclinical
项目研究机构: Johnson & Johnson (Originator)
合成路线:The cyclization of 2-oxoacetic acid ethyl ester (I),1-phenylethylamine (II) and cyclopentadiene (III) by means of BF3 and TFA in dichloromethane gives the 2-azabicyclo[2.2.1]heptene (IV),which is debenzylated with H2 over Pd/C in ethanol to yield 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester (V) The acylation of (V) with 5-chloro-2-nitrobenzoyl chloride (VI) and TEA in dichloromethane affords the bicyclic amide (VII),which is submitted to a reductive cyclization with Fe in refluxing acetic acid to afford the polycyclic benzodiazepinedione (VIII).The reduction of the carbonyl groups of (VIII) by means of LiAlH4 in THF provides the benzodiazepine (IX),which is acylated with 4-nitrobenzoyl chloride (X) and TEA in dichloromethane to give the polycyclic amide (XI).The reduction of the nitro group of (XI) with Zn and NH4Cl in refluxing methanol yields the corresponding amino derivative (XII),which is finally acylated with 4'-methylbiphenyl-2-carbonyl chloride (XIII) and TEA in dichloromethane to furnish the target polycyclic benzodiazepine.