新产品编号:2292827
Chemical Name: 1-[5-(Biphenyl-4-yloxy)pentyl]-3-(4-pyridyl)imidazolidin-2-one
项目整合开发状态: Biological Testing
项目研究机构: National Health Research Institutes (Originator)
合成路线:The reaction of pyridine-4-amine (I) with 2-chloroethyl isocyanate (II) in toluene gives N-(2-chloroethyl)-N'-(4-pyridyl)urea (III),which is cyclized by means of NaH in DMF/THF,yielding 1-(4-pyridyl)imidazolidin-2-one (IV).Finally,this compound is condensed with 4-(5-bromopentyloxy)biphenyl (V) by means of NaH in DMF to afford the target disubstituted imidazolidinone.(1,2)
📌 参考资料/链接：
参考文献标题:Imidazolidinone cpds.
文献作者:Hsu,M.-C.; Li,W.-T.; Chang,C.-M.; Shia,K.-S.; Shih,S.-R.; Chern,J.-H.; Chen,S.-J.(National Health Research Institutes)
参考来源:US 2003087936; US 6706739
📄 详细内容
合成路线:The reaction of pyridine-4-amine (I) with 2-chloroethyl isocyanate (II) in toluene gives N-(2-chloroethyl)-N'-(4-pyridyl)urea (III),which is cyclized by means of NaH in DMF/THF,yielding 1-(4-pyridyl)imidazolidin-2-one (IV).Finally,this compound is condensed with 4-(5-bromopentyloxy)biphenyl (V) by means of NaH in DMF to afford the target disubstituted imidazolidinone.(1,2)
参考文献标题:Design,synthesis,and structure-activity relationship of pyridyl imidazolidinones: A novel class of potent and selective human enterovirus 71 inhibitors
文献作者:Shia,K.-S.; Li,W.-T.; Chang,C.-M.; Hsu,M.C.; Chern,J.H.; Leong,M.K.; Tseng,S.N.; Lee,C.C.; Lee,Y.C.; Chen,S.J.; Peng,K.C.; Tseng,H.Y.; Chang,Y.L.; Tai,C.L.; Shih,S.R.
参考来源:J Med Chem 2002,45(8),1644