LM-1685
Chemical Name: 1-(4-Chlorobenzyl)-5-(methylsulfonyl)-1H-indole-2-carboxylic acid methyl ester
项目整合开发状态: Biological Testing
项目研究机构: Menarini (Originator)
合成路线:The title compound was obtained by the alkylation of methyl 5-(methylsulfonyl)indole-2-carboxylate (I) with 4-chlorobenzyl bromide (II) in the presence of KOH.
📌 参考资料/链接：
参考文献标题:Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models
文献作者:Palomer,A.; Cabr? F.; Pascual,J.; Campos,J.; Trujillo,M.A.; Entrena,A.; Gallo,M.A.; Garc�? L.; Maule�? D.; Espinosa,A.
参考来源:J Med Chem 2002,45(7),1402