新产品编号:2288081
Chemical Name: N-[4-(2-Benzothiazolyl)phenyl]-N-[11C]methylamine
项目整合开发状态: Preclinical
项目研究机构: University of Pittsburgh (Originator)
合成路线:Condensation of 2-aminothiophenol (I) with 4-nitrobenzoyl chloride (II) produces the benzothiazole (III).Reduction of the nitro group of (III) by means of SnCl2 in refluxing EtOH yields aniline (IV).Then,alkylation of (IV) with 11C-labeled iodomethane gives rise to the target 11C-methylated aniline.
📌 参考资料/链接：
参考文献标题:Thioflavin derivs.for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
文献作者:Wang,Y.; Klunk,W.E.; Mathis,C.A.Jr.(University of Pittsburgh)
参考来源:WO 0216333
📄 详细内容
合成路线:Condensation of 2-aminothiophenol (I) with 4-nitrobenzoyl chloride (II) produces the benzothiazole (III).Reduction of the nitro group of (III) by means of SnCl2 in refluxing EtOH yields aniline (IV).Then,alkylation of (IV) with 11C-labeled iodomethane gives rise to the target 11C-methylated aniline.
参考文献标题:A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
文献作者:Mathis,C.A.; Bacskai,B.J.; Kajdasz,S.T.; McLellan,M.E.; Frosch,M.P.; Hyman,B.T.; Holt,D.P.; Wang,Y.; Huang,G.F.; Debnath,M.L.; Klunk,W.E.
参考来源:Bioorg Med Chem Lett 2002,12(3),295