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新产品编号:2231129

Chemical Name: 7-[4-[4-[4-(3-Carboxy-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinolin-7-yl)piperazin-1-ylmethyl]benzyl]piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
项目整合开发状态: Biological Testing
项目研究机构: Wayne State University (Originator)
合成路线:The alkylation of ciprofloxacin (I) with bis(chloromethyl)benzene (II) afforded the monosubstituted adduct (III).This was further condensed with norfloxacin (IV) to yield the title heterodimer compound.
📌 参考资料/链接:
参考文献标题:Synthesis and antibacterial activity of novel piperazinyl-linked fluoroquinolones
文献作者:Grucz,R.G.; Kerns,R.J.; Kaatz,G.W.; Vaka,F.; Rybak,M.J.
参考来源:41st Intersci Conf Antimicrob Agents Chemother (Dec 16 2001,Chicago) 2001,Abst F-565