新产品编号:2129881

Chemical Name: (-)-2-[1(S)-(Biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole oxalate
项目整合开发状态: Preclinical
项目研究机构: Universit?degli Studi di Bari (Originator), Universit?degli Studi di Camerino (Originator), Universit?degli Studi di Modena (Originator), Universit?Louis Pasteur (Originator)
合成路线:The title compound is prepared starting from the known (S) methyl 2-(biphenyl-2-yloxy)propionate (I).Treatment of ester (I) with ethylenediamine (II) in the presence of AlMe3 gives rise to the corresponding imidazoline (II) with some loss of optical purity.Enantiomeric enrichment of (II) is accomplished by fractional crystallization with (-)-di-O,O'-p-toluoyl-L-tartaric acid.The optically pure imidazoline is finally isolated as the corresponding oxalate salt.