新产品编号:2114061

Chemical Name: (3beta,5alpha)-3-[N-[3,3-Bis(3-carboxy-5-chloro-4-methoxyphenyl)propenoyl]-N-[6,6-bis(3-carboxy-5-chloro-4-methoxyphenyl)-5-hexenyl]amino]cholestane
项目整合开发状态: Biological Testing
项目研究机构: Katholieke Universiteit Leuven (Originator), Purdue University (Originator), Southern Research Institute (Originator)
合成路线:Reductive alkylation of 3-beta-aminocholestane (I) with the known aldehyde (II) using sodium triacetoxyborohydride provided the secondary amine (III).This was then coupled with carboxylic acid (IV) in the presence of EDC and HOBt to afford the corresponding amide (V).

合成路线:Finally,basic hydrolysis of the methyl ester groups of (V) gave rise to the title compound.