新产品编号:2098241
Chemical Name: 5-[2-[4-(1H-Imidazol-1-ylmethyl)phenoxy]ethoxy]-2,3-diphenylpyrazine
项目整合开发状态: Preclinical
项目研究机构: SSP (Originator)
合成路线:Alkylation of 5,6-diphenyl-2-pyrazinol (I) with mesylate derivative (II) furnishes the pyrazinyl ether (III).The aldehyde function of (III) is then reduced to alcohol (IV) employing NaBH4 in EtOH.Chlorination of alcohol (IV) by means of SOCl2 in the presence of catalytic DMF leads to the benzyl chloride (V).This is finally condensed with imidazole (VI) in hot DMF to yield the title compound
📌 参考资料/链接：
参考文献标题:Imidazole derivs.or salts thereof and drugs containing the derivs.or the salts
文献作者:Takeda,S.; Sato,S.; Takahashi,Y.; Nagao,Y.; Konno,F.; Ohtsuka,M.; Isomae,K.; Honda,H.; Hirota,H.; Kawamoto,N.; Ishii,F.(SSP Co.,Ltd.)
参考来源:EP 1295880; WO 0200648
📄 详细内容
合成路线:Alkylation of 5,6-diphenyl-2-pyrazinol (I) with mesylate derivative (II) furnishes the pyrazinyl ether (III).The aldehyde function of (III) is then reduced to alcohol (IV) employing NaBH4 in EtOH.Chlorination of alcohol (IV) by means of SOCl2 in the presence of catalytic DMF leads to the benzyl chloride (V).This is finally condensed with imidazole (VI) in hot DMF to yield the title compound
参考文献标题:Novel anti-inflammatory agents with NO (nitric oxide) inhibition
文献作者:Konno,F.; Honda,H.; Ishii,F.; et al.
参考来源:21st Symp Med Chem (Nov 28 2001,Kyoto) 2001,Abst 2P-24