SPI-339, NEO-339
Chemical Name: 4-[3-(4-Oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)propionamido]benzoic acid ethyl ester
项目整合开发状态: Preclinical
项目研究机构: Spectrum Pharmaceuticals (Originator)
合成路线:The reaction of 4-aminobenzoic acid ethyl ester (I) with acryloyl chloride (II) by means of TEA in dichloromethane gives the corresponding acrylamide (III),which is condensed with 4,5,6,7-tetrahydro-1H-indol-4-one (IV) by means of K2CO3 in hot DMF to yield NEO-339.(1,2)
📌 参考资料/链接：
参考文献标题:Synthesis and methods of use of tetrahydroisoindolone analogues and derivs.
文献作者:Foreman,M.M.; Glasky,A.J.; Fick,D.B.(Spectrum Pharmaceuticals,Inc.)
参考来源:EP 1383742; WO 0285856
📄 详细内容
合成路线:The reaction of 4-aminobenzoic acid ethyl ester (I) with acryloyl chloride (II) by means of TEA in dichloromethane gives the corresponding acrylamide (III),which is condensed with 4,5,6,7-tetrahydro-1H-indol-4-one (IV) by means of K2CO3 in hot DMF to yield NEO-339.(1,2)
参考文献标题:Search,design and discovery of NEO-339,a novel agent that increases attentional processes associated with cognition
文献作者:Mohan,P.; Fick,D.B.; McKinley,L.K.; Prigaro,B.J.; Pfadenhauer,E.; Helton,D.
参考来源:224th ACS Natl Meet (Aug 18 2002,Boston) 2002,Abst MEDI 249