DDE-934

Chemical Name: N-[2-(5-Bromothien-2-yl)ethyl]-N'-(5-chloropyridin-2-yl)thiourea
项目整合开发状态: Biological Testing
项目研究机构: Parker Hughes Institute (Originator)
合成路线:2-(2-Thienyl)ethylamine (I) was protected as the N-Boc derivative (II) with Boc2O in CHCl3.Regioselective halogenation of the thiophene ring of (II) with concomitant Boc group cleavage by means of bromine in cold HOAc yielded the 5-bromothiophene (III).The thioimidazolide (VI) was prepared by reaction of 2-amino-5-chloropyridine (IV) with thiocarbonyl diimidazole (V).Finally,condensation of (VI) with amine (III) in hot DMF furnished the target thiourea.